Recombinant Human Noggin protein(Active)
重组人Noggin蛋白可与转化生长因子-β家族的配体结合，通过抑制其与信号受体的通路来调节其活性。
在类器官培养中，Noggin作为骨形态发生蛋白的抑制剂，调节细胞分化、增殖和凋亡。此外，其还能促进某些癌症的骨转移，并与原发性骨恶性肿瘤的发生有关。Noggin在多类肿瘤的培养系统中起到作用，如胃癌、肠癌、肝癌、胰腺癌、乳腺癌、前列腺癌等。与转化生长因子β（TGF-β）超家族成员相比，该蛋白能更有效地扩散穿过细胞外基质，可能在形成形态发生梯度中起主要作用。该蛋白在发育早期和后期均表现出多效性影响。
| 产品名称 | Recombinant Human Noggin protein(Active) |
| 货号 | RSQ-CC003 |
|
蛋白构建 |
Uniprot ID:Q13253(28-232aa) |
| 别名 | |
| 表达宿主 | E.coli |
| 种属 | Homo sapiens (Human) |
| 纯度 | Greater than 85% as determined by SDS-PAGE. |
| 内毒素 | No test |
| 缓冲液 | If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. |
| 存储 | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃. |
| 类别 | Protein |
| 用途 | For research use only |
